Molecular Genetic Analysis of PRKAG2 in Sporadic Wolff‐Parkinson‐White Syndrome
Identifieur interne : 001741 ( Main/Exploration ); précédent : 001740; suivant : 001742Molecular Genetic Analysis of PRKAG2 in Sporadic Wolff‐Parkinson‐White Syndrome
Auteurs : Carl J. Vaughan ; Yolanda Hom ; Daniel A. Okin ; Deborah A. Mcdermott ; Bruce B. Lerman [États-Unis] ; Craig T. BassonSource :
- Journal of Cardiovascular Electrophysiology [ 1045-3873 ] ; 2003-03.
English descriptors
Abstract
Introduction: Mutations in the PRKAG2 gene that encodes the gamma2 regulatory subunit of AMP‐activated protein kinase have been shown to cause autosomal dominant Wolff‐Parkinson‐White (WPW) syndrome associated with hypertrophic cardiomyopathy. Prior studies focused on familial WPW syndrome associated with other heart disease such as hypertrophic cardiomyopathy. However, such disease accounts for only a small fraction of WPW cases, and the contribution of PRKAG2 mutations to sporadic isolated WPW syndrome is unknown. Methods and Results: Subjects presented for clinical electrophysiologic evaluation of suspected WPW syndrome. WPW syndrome was diagnosed by ECG findings and/or by clinically indicated electrophysiologic study prior to enrollment. Echocardiography excluded hypertrophic cardiomyopathy. Denaturing high‐performance liquid chromatography and automated sequencing were used to search for PRKAG2 mutations. Twenty‐six patients without a family history of WPW syndrome were studied. No subject had cardiac hypertrophy, and only one patient had associated congenital heart disease. Accessory pathways were detected at diverse locations within the heart. Two polymorphisms in PRKAG2 were detected. [inv6+36insA] occurred in intron 6 in 4 WPW patients and [inv10+10delT] in intron 10 in 1 WPW patient. Both occurred in normal unrelated chromosomes. No PRKAG2 mutations were detected. Conclusion: This study shows that, unlike familial WPW syndrome, constitutional mutation of PRKAG2 is not commonly associated with sporadic WPW syndrome. Although polymorphisms within the PRKAG2 introns were identified, there is no evidence that these polymorphisms predispose to accessory pathway formation because their frequency is similarly high in both WPW patients and normal individuals. Further studies are warranted to identify the molecular basis of common sporadic WPW syndrome. (J Cardiovasc Electrophysiol, Vol. 14, pp. 263‐268, March 2003)
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DOI: 10.1046/j.1540-8167.2003.02394.x
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Vaughan</name></author><author><name sortKey="Hom, Yolanda" sort="Hom, Yolanda" uniqKey="Hom Y" first="Yolanda" last="Hom">Yolanda Hom</name></author><author><name sortKey="Okin, Daniel A" sort="Okin, Daniel A" uniqKey="Okin D" first="Daniel A." last="Okin">Daniel A. Okin</name><affiliation><wicri:noCountry code="no comma">Molecular Cardiology Laboratory</wicri:noCountry></affiliation></author><author><name sortKey="Mcdermott, Deborah A" sort="Mcdermott, Deborah A" uniqKey="Mcdermott D" first="Deborah A." last="Mcdermott">Deborah A. Mcdermott</name><affiliation><wicri:noCountry code="no comma">Molecular Cardiology Laboratory</wicri:noCountry></affiliation></author><author><name sortKey="Lerman, Bruce B" sort="Lerman, Bruce B" uniqKey="Lerman B" first="Bruce B." last="Lerman">Bruce B. Lerman</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Electrophysiology Laboratory, Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, The New York‐Presbyterian Hospital, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Basson, Craig T" sort="Basson, Craig T" uniqKey="Basson C" first="Craig T." last="Basson">Craig T. Basson</name><affiliation><wicri:noCountry code="no comma">Molecular Cardiology Laboratory</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Cardiovascular Electrophysiology</title><idno type="ISSN">1045-3873</idno><idno type="eISSN">1540-8167</idno><imprint><publisher>Blackwell Science Inc</publisher><pubPlace>350 Main Street , Malden , MA 02148 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK .</pubPlace><date type="published" when="2003-03">2003-03</date><biblScope unit="volume">14</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="263">263</biblScope><biblScope unit="page" to="268">268</biblScope></imprint><idno type="ISSN">1045-3873</idno></series><idno type="istex">5B6D25995E416287ECEAFBC5505684D3E60F8D2A</idno><idno type="DOI">10.1046/j.1540-8167.2003.02394.x</idno><idno type="ArticleID">JCE02394</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1045-3873</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Wolff‐Parkinson‐White syndrome</term><term>accessory pathway</term><term>genetics</term><term>preexcitation</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Introduction: Mutations in the PRKAG2 gene that encodes the gamma2 regulatory subunit of AMP‐activated protein kinase have been shown to cause autosomal dominant Wolff‐Parkinson‐White (WPW) syndrome associated with hypertrophic cardiomyopathy. Prior studies focused on familial WPW syndrome associated with other heart disease such as hypertrophic cardiomyopathy. However, such disease accounts for only a small fraction of WPW cases, and the contribution of PRKAG2 mutations to sporadic isolated WPW syndrome is unknown. Methods and Results: Subjects presented for clinical electrophysiologic evaluation of suspected WPW syndrome. WPW syndrome was diagnosed by ECG findings and/or by clinically indicated electrophysiologic study prior to enrollment. Echocardiography excluded hypertrophic cardiomyopathy. Denaturing high‐performance liquid chromatography and automated sequencing were used to search for PRKAG2 mutations. Twenty‐six patients without a family history of WPW syndrome were studied. No subject had cardiac hypertrophy, and only one patient had associated congenital heart disease. Accessory pathways were detected at diverse locations within the heart. Two polymorphisms in PRKAG2 were detected. [inv6+36insA] occurred in intron 6 in 4 WPW patients and [inv10+10delT] in intron 10 in 1 WPW patient. Both occurred in normal unrelated chromosomes. No PRKAG2 mutations were detected. Conclusion: This study shows that, unlike familial WPW syndrome, constitutional mutation of PRKAG2 is not commonly associated with sporadic WPW syndrome. Although polymorphisms within the PRKAG2 introns were identified, there is no evidence that these polymorphisms predispose to accessory pathway formation because their frequency is similarly high in both WPW patients and normal individuals. Further studies are warranted to identify the molecular basis of common sporadic WPW syndrome. (J Cardiovasc Electrophysiol, Vol. 14, pp. 263‐268, March 2003)</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><noCountry><name sortKey="Basson, Craig T" sort="Basson, Craig T" uniqKey="Basson C" first="Craig T." last="Basson">Craig T. Basson</name><name sortKey="Hom, Yolanda" sort="Hom, Yolanda" uniqKey="Hom Y" first="Yolanda" last="Hom">Yolanda Hom</name><name sortKey="Mcdermott, Deborah A" sort="Mcdermott, Deborah A" uniqKey="Mcdermott D" first="Deborah A." last="Mcdermott">Deborah A. Mcdermott</name><name sortKey="Okin, Daniel A" sort="Okin, Daniel A" uniqKey="Okin D" first="Daniel A." last="Okin">Daniel A. Okin</name><name sortKey="Vaughan, Carl J" sort="Vaughan, Carl J" uniqKey="Vaughan C" first="Carl J." last="Vaughan">Carl J. Vaughan</name></noCountry><country name="États-Unis"><region name="État de New York"><name sortKey="Lerman, Bruce B" sort="Lerman, Bruce B" uniqKey="Lerman B" first="Bruce B." last="Lerman">Bruce B. Lerman</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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